Recovery Outcomes of Schizophrenia Patients Treated with Paliperidone Palmitate in a Community Setting: Patient and Provider Perspectives on Recovery

Wesley Williams PhD, Christopher McKinney PhD, Larry Martinez PhD & Carmela Benson MS, MSHP (2015) Journal of Medical Economics. Vol. Published Online. Page(s): 1-8.


Objectives: This study evaluated the effect of paliperidone palmitate long-acting injectable (LAI) antipsychotic on recovery-oriented mental health outcomes from the perspective of healthcare providers and patients during the treatment of patients with schizophrenia or schizoaffective disorders.

Methods: Archival data for patients with a primary diagnosis of schizophrenia or schizoaffective disorder receiving ≥6 months of paliperidone palmitate LAI were retrieved from the electronic medical records system at the Mental Health Center of Denver. Mental health recovery was assessed from both a provider’s (Recovery Markers Inventory [RMI]) and patient’s (Consumer Recovery Measure [CRM]) perspective. A three-level hierarchical linear model (HLM) was utilized to determine changes in CRM and RMI scores by including independent variables in the models: intercept, months from treatment (slope), treatment time period (pretreatment and treatment), age, gender, primary diagnosis, substance abuse diagnosis, concurrent medications, and adherence to paliperidone palmitate LAI.

Results: A total of 219 patients were identified and included in the study. Results of the final three-level HLMs indicated an overall increase in CRM scores (p<0.05) and an overall increase (p<0.01) and increased rate of change (p<0.05) in RMI scores during the paliperidone palmitate LAI treatment period versus the pretreatment period.

Limitations: This study contained a retrospective, non-comparative design and did not adjust for multiplicity

Conclusions: The current study demonstrates that changes in recovery-oriented mental health outcomes can be detected following the administration of a specific antipsychotic treatment in persons with schizophrenia or schizoaffective disorders. Furthermore, patients receiving paliperidone palmitate LAI can effectively improve recovery-oriented outcomes, thereby supporting the drug’s use as schizophrenia treatment from a recovery-oriented perspective.


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Resource Topics: Clinical Outcomes Keywords: Schizophrenia Patients Treated with Paliperidone Palmitate in a Community Setting